http://politiken.dk/videnskab/article549039.ece

Nogen der har erfaringer med produktet?

Det lyder jo umiddelbart interessant - men nu vides det jo endnu ikke om studierne kan overføres til mennesker og indtil da vælger jeg at stille mig lidt kritisk over for det.

I tilfælde af det rent faktisk skulle virke skal de overvægtige mennesker alligevel først på en seriøs diæt i 6 måneder og så er der nok en hel del der alligevel tabes i svinget.

Her er en anmeldse af produktet:

By: Mr L. Heaton

Among its primary function in the body, where it is converted into lipoamide, is to activate enzymes that handle energy producing molecules, such as pyruvate, and to break down products from amino acids. Basically, ALA helps us collect energy and nutrients from the food we eat. The body needs ALA to produce energy. It plays a crucial role in the mitochondria, the energy-producing structures in cells. The body actually makes enough ALA for these basic metabolic functions. This compound acts as an antioxidant, however, only when there is an excess of it and it is in the "free" state in the cells[9]. But there is little free ALA circulating in your body, unless you consume supplements or get it injected. Foods contain only tiny amounts of it. What makes ALA special as an antioxidant is its versatility; it helps deactivate an unusually wide array of cell-damaging free radicals in many bodily systems[10]. In particular, ALA helps protect the mitochondria and the genetic material, DNA. As we age, mitochondrial function is impaired, and it is theorized that this may be an important contributor to some of the adverse effects of aging. ALA also works closely with vitamin C and E and some other antioxidants, "recycling" them and thus making them much more effective As mentioned earlier, ALA plays a large role as an anti-oxidant. It is such a powerful antioxidant that some researches have dubbed it the "universal antioxidant." Through studies, ALA has shown that it works in conjunction with vitamins C and E, to help improve their effectiveness in combating free radicals, as mentioned earlier [7]. Research has even shown that ALA can actually replace the function of vitamin C in animals deficient in vitamin C [4]. This is especially important to bodybuilders because intense physical activity such as weight training or extreme cardio can cause extreme oxidative damage, letting loose many free radicals in the body. That is why antioxidants, both natural and supplemental, are critical to bodybuilders. When ALA is on its own it can directly neutralize free radicals both in membranes and insides cells because it is both water and fat soluble [11]. This ability to neutralize free radicals is an extremely important benefit of lipoic acid. Yet it is in union with other antioxidants that ALA can really show its strength. ALA can mimic other antioxidants but also improve their performance because it replenishes them [12]. When one antioxidant molecule neutralizes a free radical, it actually turns it into a stable form. Then in a chemical reaction the free radical is eventually passed off to lipoic acid or glutathione molecule, which allows the original antioxidant to regenerate and neutralize more free radicals while ALA washes out the offending free radical [18]. Glutathione, ALA's wingman in this disposal process, is also a critical antioxidant. Alpha Lipoic Acid supplementation has been shown to boost glutathione levels, which drop significantly during periods of exercise induced stress by up to 50% [6]. When large amounts of free alpha-lipoic acid are available, such as with supplementation, alpha-lipoic acid is also able to function as an antioxidant [3]. Alpha-dihydrolipoic acid (DHLA) is the reduced form of alpha-lipoic acid, and is the only form that functions directly as an anti-oxidant. Free alpha lipoic acid is rapidly taken up by cells and reduced to DHLA intracellularly. Because DHLA is also rapidly eliminated from cells, the extent to which its antioxidant effects can be sustained remain unclear. Although only DHLA functions directly as an antioxidant, alpha lipoic acid may have indirect antioxidant effects [2]. ALA also increases intracellular glutathione levels. Glutathione is an important water-soluble antioxidant that is synthesized from the sulfur-containing amino acid cysteine. The availability of cysteine inside a cell determines its rate of glutathione synthesis. DHLA has been found to increase the uptake of cysteine by cells in culture, leading to increased glutathione synthesis [1]. Although increases in intracellular DHLA are short-lived, DHLA may also improve intracellular antioxidant capacity by inducing glutathione synthesis. if this has helped you.

Dety lyder engetlig som et rimelig godt produkt

essensen skrev:Det lyder jo umiddelbart interessant - men nu vides det jo endnu ikke om studierne kan overføres til mennesker og indtil da vælger jeg at stille mig lidt kritisk over for det.

I tilfælde af det rent faktisk skulle virke skal de overvægtige mennesker alligevel først på en seriøs diæt i 6 måneder og så er der nok en hel del der alligevel tabes i svinget.

Ja, det har du helt ret i. Det kræver lidt nærmere undersøgelser, men det er da potentielt ret interessant hvad man kan bruge det til

ThaChamp: Lækker anmeldelse du fandt der

Nogle der ved om det kan købes i dk iøvrigt eller skal det hentes hjem fra udlandet?

Ved at visse træningsfolk allerede benytter dette produkt,
og gør det med succes, både under cut og bulk ..

Det er muligt at bestille fra dk og andre EU-lande!
Det "gemmer" sig under forkortelsen ALA, hertil skal
det siges at der også findes et produkt kaldet R-ALA

Forskellen på disse to produkter er sjovt nok effektiviteten!
ALA (Alpha Lipoic Acid) indeholder 50% R-Isomer og 50% S-Isomer,
stort set alle de positive virkninger skal findes i R-isomerne!

R-ALA er udelukkende 100% R-isomer, hvilket er grunden til
at denne form er mere effektiv ..

Søg blot på google efter ALA eller R-ALA, så skulle der
gerne dukke nogen netforhandlere op!

Så vidt jeg er informeret skulle det være billigere at
finde produktet i pulverform, hvorvidt dette er muligt
i DK eller andre EU-lande skal jeg ikke kunne sige

jeg har benyttet ALA et par gange unde cut. jeg synes ikke at jeg havde lettere ved at smide fedt når jeg brugte det end når jeg ikke gjorde.

der er en del bodybuildere der fortæller at de benytter der under bulk, og faktisk holder deres bf nede med det. så det kan da komme an på en prøv. ALA koster ikke ret mange bas'øre

Så hvis jeg har forstået det korrekt:
- Man indtager det under cut, hvorefter man senere hen bulker med det. Hvorså man bedre kan holde sin bf nede, pga. noget jeg ikke helt har fattet

Noget jeg ligefandt om R-ALA

http://www.ralapure.com/musclefat.asp?page=2

"Benefits for Fat Loss and Muscle Building
Immediately following your workout, the carbs you eat cause an insulin spike. Using R-ALA, you can channel more of the glucose to the muscle cells instead of the fat cells gaining more lean muscle mass without a concurrent gain in body fat.

Of particular interest to the bodybuilder is the fact that r-ALA enables the muscles to increase the amount of glucose that they absorb from the blood stream by increasing the number of glut-4 transporters on the out-side of the myocites (muscle-cells) by almost 50%. By forcing the glucose and nutrients into both the MUSCLE-cells and the fat-cells, one can use ALA as a nutrient-partitioning agent.

The net result is an increased muscle-gain over the long run with a smaller fat-gain. To give you a quantitative idea, if a person gains 10lbs muscle and 10lbs fat in a bulking cycle w/o ALA. He/she is likely to gain around 14lbs muscle and 6 lbs fat if he/she would have taken ALA. "

Bork skrev:Så hvis jeg har forstået det korrekt:
- Man indtager det under cut, hvorefter man senere hen bulker med det. Hvorså man bedre kan holde sin bf nede, pga. noget jeg ikke helt har fattet

du behøver ikke bruge det under cut. men det kan du godt.
men ja.. nogen hævder at man holder sin bf nede når man bruger ALA.

Skal ikke kunne sige noget om det passer, men den her artikel er ikke særligt positiv over det:
http://www.t-nation.com/readArticle.do?id=1004313

Hm, spændende læsning. Den undersøgelse (14) som de refererer til er her:

http://www.ncbi.nlm.nih.gov/pubmed/15068957

We have shown previously (Saengsirisuwan V, Kinnick TR, Schmit MB, and Henriksen EJ. J Appl Physiol 91: 145-153, 2001) that the antioxidant R-(+)-alpha-lipoic acid (R-ALA), combined with endurance exercise training (ET), increases glucose transport in insulin-resistant skeletal muscle in an additive fashion. The purpose of the present study was to investigate possible cellular mechanisms responsible for this interactive effect. We evaluated the effects of R-ALA alone, ET alone, or R-ALA and ET in combination on insulin-stimulated glucose transport, protein expression, and functionality of specific insulin-signaling factors in soleus muscle of obese Zucker (fa/fa) rats. Obese animals remained sedentary, received R-ALA (30 mg.kg body wt(-1).day(-1)), performed ET (daily treadmill running for < or =60 min), or underwent both R-ALA treatment and ET for 15 days. R-ALA or ET individually increased (P < 0.05) insulin-mediated (5 mU/ml) glucose transport (2-deoxyglucose uptake) in soleus muscle by 45 and 68%, respectively, and this value was increased to the greatest extent (124%) in the combined treatment group. Soleus insulin receptor substrate (IRS)-1 protein was significantly increased by R-ALA alone (30%) or ET alone (31%), and a further enhancement (55%) was observed after the combination treatment in the obese animals. Enhanced levels of IRS-1 protein expression after individual or combined interventions were significantly correlated with insulin action on glucose transport activity (r = 0.597, P = 0.0055). Similarly, insulin-mediated IRS-1 associated with the p85 regulatory subunit of phosphatidylinositol 3-kinase was increased by R-ALA (317%) and ET (319%) and to the greatest extent (435%) (all P < 0.05) by the combination treatment. These results indicate that the improvements of insulin action in insulin-resistant skeletal muscle after R-ALA or ET, alone and in combination, were associated with increases in IRS-1 protein expression and IRS-1 associated with p85.

Jeg kan ikke se nogen steder i den artikel at der skulle påføres oxidative skader af ala...
Hmm, jeg er nu heller ikke vant til at læse medicinske skrifter så det er måske derfor...

Ghâshûl skrev:Jeg kan ikke se nogen steder i den artikel at der skulle påføres oxidative skader af ala...
Hmm, jeg er nu heller ikke vant til at læse medicinske skrifter så det er måske derfor...

Jeg kan heller ikke se det Måske han har byttet om på kildehenvisningerne? Jeg magter bare ikke lige at skulle kigge dem alle igennem. Gør det måske imorgen.

Lidt pudsigt iøvrigt, at den artikel som han mener er den største fortaler for ikke at indtage ALA ikke er linket til ligesom de andre. Når man så endelig finder den på google så konkluderer den noget andet end det han skriver? Eller er det mig der (også) er blind?

Det må da være den rigtige så vist jeg kan se.

Det er den rigtige titel: Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats.

Tror ikke der er nogen tvivl om det.
Han kan selvfølgelig have byttet rundt på dem, så det i virkeligheden ikke skulle stå (14) men et andet tal, lige der hvor han henviser.

Ghâshûl skrev:Det er den rigtige titel: Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats.

Tror ikke der er nogen tvivl om det.
Han kan selvfølgelig have byttet rundt på dem, så det i virkeligheden ikke skulle stå (14) men et andet tal, lige der hvor han henviser.

Tja, jeg kan ikke lige gennemskue det. Har skimmet de andre referencer uden lige umiddelbart at kunne finde noget der understøtter det. Jeg fik en fejlmelding da jeg forsøgte at oprette mig som bruger derinde

Friche skrev:Hm, spændende læsning. Den undersøgelse (14) som de refererer til er her:

http://www.ncbi.nlm.nih.gov/pubmed/15068957

We have shown previously (Saengsirisuwan V, Kinnick TR, Schmit MB, and Henriksen EJ. J Appl Physiol 91: 145-153, 2001) that the antioxidant R-(+)-alpha-lipoic acid (R-ALA), combined with endurance exercise training (ET), increases glucose transport in insulin-resistant skeletal muscle in an additive fashion. The purpose of the present study was to investigate possible cellular mechanisms responsible for this interactive effect. We evaluated the effects of R-ALA alone, ET alone, or R-ALA and ET in combination on insulin-stimulated glucose transport, protein expression, and functionality of specific insulin-signaling factors in soleus muscle of obese Zucker (fa/fa) rats. Obese animals remained sedentary, received R-ALA (30 mg.kg body wt(-1).day(-1)), performed ET (daily treadmill running for < or =60 min), or underwent both R-ALA treatment and ET for 15 days. R-ALA or ET individually increased (P < 0.05) insulin-mediated (5 mU/ml) glucose transport (2-deoxyglucose uptake) in soleus muscle by 45 and 68%, respectively, and this value was increased to the greatest extent (124%) in the combined treatment group. Soleus insulin receptor substrate (IRS)-1 protein was significantly increased by R-ALA alone (30%) or ET alone (31%), and a further enhancement (55%) was observed after the combination treatment in the obese animals. Enhanced levels of IRS-1 protein expression after individual or combined interventions were significantly correlated with insulin action on glucose transport activity (r = 0.597, P = 0.0055). Similarly, insulin-mediated IRS-1 associated with the p85 regulatory subunit of phosphatidylinositol 3-kinase was increased by R-ALA (317%) and ET (319%) and to the greatest extent (435%) (all P < 0.05) by the combination treatment. These results indicate that the improvements of insulin action in insulin-resistant skeletal muscle after R-ALA or ET, alone and in combination, were associated with increases in IRS-1 protein expression and IRS-1 associated with p85.

Overvejer selv at prøve r-ala. Men er total skod til engelsk, så er der nogen der kan fortælle lidt mere om den artikel og hvad de mener der skulle være dårligt ved det?

Her er google translates bud:




Vi har vist tidligere (Saengsirisuwan V, Kinnick TR, Schmit MB, og Henriksen EJ. J Appl Physiol 91: 145-153, 2001), at antioxidant R-(+)-alpha-lipoic acid (R-ALA), kombineret med Holdbarhedsprøven udøve uddannelse (ET), stiger glucose transport i insulin-resistente skeletmuskulatur i et tilsætningsstof måde. Formålet med denne undersøgelse var at undersøge mulige cellulære mekanismer ansvarlige for denne interaktive virkning. Vi har evalueret effekten af R-ALA alene, ET alene eller R-ALA og ET i kombination med insulin-stimuleret glukose transport, protein udtryk og funktionalitet af specifikke insulin-signaling faktorer i soleus muskel af obese Zucker (fa / fa) rotter. Fede dyr forblev stillesiddende, modtaget R-ALA (30 mg.kg organ WT (-1). Dag (-1)), udføres ET (daglig treadmill kører for

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